Brady finished 28 of 49 for 342 yards with two touchdowns and two interceptions.
The Patriots fell to 5-3 and into a tie for first with the New York Jets and Buffalo Bills in the AFC East.
0:15 4th quarter: Giants 24, Patriots 20 -- Eli Manning threw a 1-yard TD pass with 15 seconds left to put the Giants went ahead.
The play capped an 80-yard drive that took 1:21.
The key play was Patriots safety Sergio Brown's pass interference on Giants receiver Victor Cruz that gave the Giants the ball at the Patriots 2.
1:36 4th quarter: Patriots 20, Giants 17 -- Tom Brady threw a 14-yard TD pass to Rob Gronkowski as the Patriots reclaimed the lead.
The Patriots' drive lasted only 1:27, carving up the Giants' secondary.
3:03 4th quarter: Giants 17, Patriots 13 -- Eli Manning threw a 10-yard TD pass to Mario Manningham in the corner of the end zone, giving the Giants the lead right back.
The Giants were helped on the drive by a 35-yard pass interference call on Patriots CB Kyle Arrington.
7:08 4th quarter: Patriots 13, Giants 10 -- Stephen Gostkowski added his second field goal of the game, this one a 45-yarder, as the Patriots took their first lead of the game. It capped a nine-play, 53-yard drive.
Tom Brady targeted Chad Ochocinco twice on the drive, but couldn't connect. Brady did connect with Rob Gronkowski for 27 yards.
11:03 4th quarter: Patriots 10, Giants 10 -- Vince Wilfork and Kyle Love managed to make a big stop on Giants RB D.J. Ware in the backfield, and then the Patriots got pressure on Eli Manning to force another Giants punt.
14:28 4th quarter: Patriots 10, Giants 10 -- Tom Brady threw a 5-yard TD pass to Aaron Hernandez, who made a Giants tackler miss before diving into the end zone.
The score capped a seven-play, 80-yard drive that spanned 2:41. It more closely resembled the Patriots offense we've seen throughout the year, with darting passes to Wes Welker and Hernandez. Welker caught passes of 27 and 28 yards on the drive.
End of the 3rd quarter: Giants 10, Patriots 3 -- Wes Welker now has eight grabs for 127 yards in the game. He's got the Patriots in the red zone going into the fourth quarter. It's the 20th 100-yard game for Welker in his career.
2:09 3rd quarter: Giants 10, Patriots 3 -- Patriots CB Kyle Arrington picked off Eli Manning in the back of the end zone to give the Patriots the ball back.