Boy or girl? A simple test raises ethical concerns

Some fear its use for gender selection

August 10, 2011|By Deborah Kotz, Globe Staff

Pregnant couples wishing to know the gender of their unborn baby can usually find out during a routine ultrasound performed at around 20 weeks of pregnancy, but a review published yesterday in the Journal of the American Medical Association suggests that a test of the mother’s blood performed at seven weeks may be even more reliable.

The test - which checks fetal cells in the mother’s blood for the Y chromosome present only in male cells - has been available in Europe for years but has not found its way into routine medical practice in the United States. That could change given the new review, which analyzed 57 studies involving a total of 6,500 pregnancies and found that the tests were more than 95 percent accurate at determining gender at seven weeks. By 20 weeks, the accuracy was 99 percent.

But the researchers evaluated use of the test only in medical settings in foreign countries, not direct-to-consumer procedures, which are currently the only way for pregnant women to get the test in the United States.

Given the validation of the test’s accuracy, specialists say it’s only a matter of time before doctors begin offering it here - and that could raise ethical concerns if couples terminate a pregnancy when the fetus is not the gender of their choice. In some countries, including India and China, the percentage of girl babies has dropped precipitously in recent years, probably because of gender selection in favor of boys.

“If couples can get the results earlier, that makes abortion less burdensome,’’ said Arthur Caplan, a bioethicist at the University of Pennsylvania. “A woman can take the test, and then take pills to terminate the pregnancy in the privacy of her home when it’s that early on. I would say gender selection is a bad reason to have an abortion, which is tough for a pro-choicer like me to admit.’’

The blood test works by detecting fragments of fetal DNA that float through the mother’s bloodstream. Scientists can identify gender by looking for markers of the Y chromosome and can assume the fetus is a girl if none are found.

While some American couples use ultrasound results as a reason to terminate a healthy pregnancy, the imaging test is not as accurate. Studies suggest it is accurate about 86 percent of the time from 11 to 14 weeks, and about 90 percent of the time beyond that.

More invasive techniques, such as amniocentesis - which involves drawing a sample of amniotic fluid via a needle - are nearly 100 percent reliable, but pose a small risk of miscarriage and can’t be performed early in pregnancy.

Advertisement
Advertisement
|
|
|
|