The domestic afflictions in “My Sister’s Keeper’’ pile onto the Fitzgerald family with biblical fury. Sixteen-year-old Kate (Sofia Vassilieva) has battled leukemia for most of her life. Eleven-year-old Anna (Abigail Breslin) has had it with being a “donor child,’’ born to provide marrow and tissue for her sister, and is suing for legal emancipation. Oldest son Jesse (Evan Ellingson) is dyslexic and doing something naughty downtown.
A pall of disaster, in fact, hangs over everyone in this shapeless, hankie-wringing adaptation of the best-selling Jodi Picoult novel. The judge in the case (Joan Cusack) is mourning a daughter dead in an accident, and Anna’s lawyer (Alec Baldwin) keeps a service dog around for reasons that become clear late in the film. And there’s the children’s mother, Sara (Cameron Diaz), a monster of maternal denial so steely she could have been played by Joan Crawford in her fire-breathing prime.