Caserio is now in line for another move from No. 2 to No. 1, and his present employers - the New England Patriots - surely hope it goes as well as it did back at John Carroll.
The 33-year-old Caserio, who has served as the Patriots' director of player personnel since last February, is expected to assume more responsibility in the front office after vice president of player personnel Scott Pioli's departure to Kansas City as general manager.
So, Patriots followers might ask, who is Nick Caserio?
A native of Lyndhurst, Ohio, he joined the Patriots in 2001 as a personnel assistant, bolstered by the recommendation of his former college teammate, Josh McDaniels. His time with the Patriots has zigzagged - he worked as an offensive coaching assistant (2002), then as an area scout (2003), was director of pro personnel (2004-06), then returned to the sideline as wide receivers coach (2007).
Caserio was moved back to the front office last February, perhaps with the thought that if Pioli finally did depart, an in-house replacement would be in place, already learning on the job.
Caserio's thirst for learning football, it turns out, goes back to his high school days at University School, a private school in the suburbs of Cleveland.
"Football is his passion," said Joe Perella, who coached Caserio for eight years, first at University School, then at John Carroll. "He was a kid you had to tell to stop, whether it was in the weight room, on the field, running. He'd just keep going, a total perfectionist.
"He's the hardest-working kid I've ever coached."
That extended to his days at John Carroll, where he beat out McDaniels at quarterback, leading the coaches to move McDaniels to receiver.
"He was someone we had to kick out of the office, that's how committed he was. Nick couldn't watch enough film in preparing himself," DeCarlo said. "It was just unbelievable, and got to the point where the assistant coaches had to go up to him and say, 'Nick, get out of here.' "
Both Perella and DeCarlo recalled that Caserio's film study helped him understand what the opposition was doing, and at quarterback, he'd often switch the play based on what he saw before the snap.